Superiority Over Nix®

Natroba is the only FDA-approved prescription head lice treatment that demonstrated clinical superiority to Nix® (permethrin 1%) in two head-to-head, phase III clinical trials. No nit combing required.2

Chart outlining Natroba™ treatment success
Chart outlining Natroba™ treatment success

In two multicenter, randomized, controlled clinical studies under actual-use conditions, significantly more patients using Natroba were lice-free (no live lice, adults or nymphs) 14 days after the last treatment without nit combing compared to permethrin with combing, 84.6% vs. 44.9% and 86.7% vs. 42.9%, respectively (P<0.001).2

Primary Endpoint: The proportion of patients who were lice free (no live lice, adults or nymphs) 14 days after the last treatment with Natroba without combing vs. permethrin with combing.

Soil microorganism at the center of the safety profile

The active ingredient in Natroba derives from a naturally occurring soil microorganism3 that differs from neurotoxic agents such as permethrins and pyrethrins4:

Scientific diagram image of how Spinosad works
  • The active compound, spinosad, is not systemically absorbed, even in patients as young as six (6) months of age5
  • Spinosad targets lice and nits where they live, not penetrating beyond the stratum corneum, before sloughing off through the natural process of non-pathologic desquamation (over approximately 14 days)2
    • In a Phase I clinical trial, fourteen (14) subjects 4-15 years of age, applied a single topical (scalp) treatment of spinosad 1.8% (double the active amount of compound in Natroba) for 10 minutes. Results demonstrated no systemic absorption of spinosad2
  • There is no evidence of neurotoxicity, developmental/reproductive toxicity, immunotoxicity, mutagenicity, or carcinogenicity from spinosad exposure2
Chart outlining most comment adverse events

Natroba has also demonstrated similar or lower treatment-related AEs than Nix® (permethrin 1%), the leading OTC medication.6

There is no known resistance to the active compound, spinosad, in head lice and cross-resistance with other insecticides has not been reported for spinosad.7